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KMID : 1101420160480020049
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Korean Journal of Clinical Laboratory Science
2016 Volume.48 No. 2 p.49 ~ p.53
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Usefulness of the Neutrophil Gelatinase-Associated Lipocalin (NGAL) Kit for Acute Kidney Injury Patients at the Emergency Medical Center in Daegu
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Lee Seung-Jin
Park Sang-Wook
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Abstract
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Acute kidney injury (AKI) is a common syndrome resulting in kidney damage and malfunction within a few days or even a few hours. The diagnosis of AKI depends on routine biochemical tests, including serum creatinine, aspartate aminotransferase (AST), alanine aminotransaminase (ALT), blood urea nitrogen (BUN), and electrolytes. Plasma neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker that shows correlation with the severity of acute infections and kidney injuries. The predictive value in other conventional assays for kidney functions has been reported to cause distraction for AKI syndrome. The aim of this study is to verify the predictive value of plasma NGAL in patients with established AKI. The NGAL kit for checkup demonstrates sensitivity of ≥300 (92.2%), ≥200 (95.6%), ≥100 (99.6%), specificity of ≥300 (95.1%), ≥200 (97.3%), ≥100 (99.4%), positive predictability of ≥300 (93.3%), ≥200 (93.4%), ≥100 (99.2%), and negative predictability of ≥300 (96.7%), ≥200 (97.7%), ≥100 (98.1%), respectively. The plasma NGAL compared with the enzyme-linked immunosorbent assay (ELISA) has been shown to be an early predictive biomarker of AKI. The NGAL kit, recently developed for point-of-care of plasma specimens, is thought to be a useful and reliable biomarker for the early diagnosis of decreased kidney functions.
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KEYWORD
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Neutrophil gelatinase-associated lipocalin (NGAL), Acute kidney injury (AKI), Biomarker, Point of care testing
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